Pregnancy Double Marker Test Complete Guide


We will learn in detail about the double marker test (DMT). why it is so important in pregnancy and the complete double marker test cost. Is it mandatory or not and the report analysis of the double marker test, you can navigate this article through the index below.


During pregnancy, many types of medical tests are done to look after the better future and health of the mother and child. These medical tests are divided into two classes.

All those tests are included in the first category, which is considered very important in terms of the health of mother and child. All these types of tests are only part of regular checkups during pregnancy.


At the same time, those tests are included in the second category, which the doctors recommend to be given in view of the possibility of any future problems. The double marker test is a similar test. Doctors recommend taking this test only if there is a possibility of a serious problem. Through this article of conjunction, we will try to know about all the special information related to this test.

First of all, it is necessary to know what is a double marker test.


What is a double marker test?

Talking about this test, it is a blood test done in the first trimester of pregnancy. It is usually done between the 10th and 14th week of conception. It detects aneuploidy (abnormal amount of chromosome) pregnancy. The special is that the double marker test is a non-invasive screening (a test without any cut marks).

Through this test, chromosomes (chromosomes) such as downgrade syndrome (trisomy 21), Edward syndrome (trisomy 18), and patau syndrome (trisomy 13) are detected. Any deficiency in the chromosome may impede fetal development or the child may face some kind of health problem after birth. The incorporation of several genes is called a chromosome.


double marker test


Need to prepare for the double marker test?

No special preparation is required before the double marker test. The reason is that it is a simple blood test, which is done with ultrasound. Yes, it is definitely not to hide any of your medical histories from the doctor. Also, if you are taking some medicines during this time, then tell your doctor about that too. You may have to stop these medicines until the test and drink sufficient water.


Why is a double marker test done?

Pregnant women who are classified as having a particular type of severe risk are required to undergo a double marker test. Seeing these serious risks, doctors recommend them to undergo this test. Let’s take a look at the risks that make it necessary for a pregnant woman to undergo a double marker test.

  • If the age of the woman is above 35 years.
  • The previous child is born with a chromosomal abnormality.
  • There is a particular genetic problem in the family.
  • Conceived by IVF (in vitro fertilization) method.
  • Women suffer from type-1 diabetes and depend on insulin.


How is double marker testing done?

The double marker test is mainly based on the Nuclear Translucency Scan ie NT. The area under the neck behind the baby’s head contains a fluid, called a Nucleo translucency. Down syndrome is detected by checking the thickness of this fluid during a nuclear translucency scan. Doctors recommend this test if Down syndrome is suspected.

Simply put, this is a blood test done with ultrasound during pregnancy. With the help of this test, doctors check the blood of a pregnant woman and check the hormones and proteins present in it. Explain that the hormone that is tested in this test is called Free Beta HCG (Human Chronic Gonadotropin). At the same time, glycoprotein (a type of protein) and PAPP-A (pregnancy-associated placenta) are tested during this test when it comes to the proteins to be included in the test.


Double Marker Test Normal Values 

Test Talk about the normal value of the double marker test, the average quantity of free beta HCG in the test results is 59,109 to 201,165 mIU / mL (milli-international units per milliliter) between the first quarter ie 9 to 12 weeks. Should be. At the same time, the amount of PAPP-A should be 1 MoM (Multiple of Median).


Double Marker Test Report Analysis

The results of this test indicate serious risks related to Down syndrome occurring in the future. These can be understood in some ways, for example, if the amount of free beta hCG found in the test exceeds the normal limit, it is considered a positive marker. This means that there are more chances of pregnancy with Down syndrome. While PAPP-A is measured less than normal in the second condition, this condition is also seen as a positive result for Down syndrome.

double marker test

The results of these tests come in ratio form. If the ratio is from 1:10 to 1: 250, it means screen positive. On the other hand, if the ratio is 1: 1000, then it means screen negative. Screen negatives are considered low threat targets. Now, let’s try to understand this ratio in easy language. A 1:10 ratio means that after 1 pregnancy, 1 baby may have this disorder. Similarly, a 1: 1000 ratio can be found in 1 infant after 1000 pregnancy disorder.

After getting positive results in both these situations, the doctor recommends further tests. These tests are necessary to confirm the risk of Down syndromes, such as amniocentesis and chorionic villus sampling (CVS) and testing of embryonic cells present in amniotic fluid.

Double Marker Test Advantages

There are several benefits of this test, which we are trying to explain here through some points.

  • If the amount of chromosome in the fetus is found to be abnormal, then there is ample time for future treatment and other tests.
  • Double marker test results are usually accurate.
  • If the results indicate an increase in complications in the future, doctors may decide to eliminate pregnancy without any risk.

Double Marker Test Disadvantages

When talking about the damage, no specific information is available at this time. Doctors recommend taking this test only when they understand its need. Despite this, there are some flaws found in everything, so this is the case with this test.

  • Mainly the losses in this test can depend on the skill of the tester and the quality of the machine.
  • Since this test cannot be done in every hospital or city, you may have to travel to another city for this.
  • This is an expensive test, so it is difficult for everyone to bear the cost.


Note- The point to note is that the double marker test is only a screening test. Its results are based on probability. It merely shows the risk of a genetic disorder. It is difficult to diagnose.


What is the Double Marker Test Cost?

Talking about the double marker test cost, on average, this test can cost up to 4 to 15 thousand. This test is not available in every city, so you may have to go to another city to get it tested. Therefore, the cost of this examination may change depending on the place and hospital.

double marker test cost

Hopefully, through the article, you have got a lot of information about the benefits, disadvantages, and complications of this test. In such a situation, if your doctor has also advised you to do this test or you are thinking of getting this test, then before reading the test, please read this article thoroughly.


Hopefully, the information given in the article will prove to be very helpful for your healthy delivery. For any other type of suggestions and questions on this topic, you can connect with us through the comment box below.


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